2. Signaling Pathways
  3. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  4. Trk Receptor
  5. Trk Receptor Activator

Trk Receptor Activator

Trk Receptor Isoform Comparison

Trk Receptor Activators (14):

Cat. No. Product Name Effect Purity
  • HY-107854
    N-Acetyl-5-hydroxytryptamine
    		Activator 99.96%
    N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.
  • HY-104047
    LM22B-10
    		Activator 99.92%
    LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.
  • HY-101446
    HIOC
    		Activator 99.94%
    HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration.
  • HY-110255
    AZD 2066
    		Activator 99.8%
    AZD-2066 is a selective, orally active and blood-brain barrier-permeating mGluR5 antagonist. AZD 2066 activates the BDNF/trkB signaling pathway. AZD 2066 can be used in the research of neuropathic pain, major depressive disorder and gastroesophageal reflux disease.
  • HY-152472
    ENT-C225
    		Activator 99.16%
    ENT-C225 is an effective activator of TrkB neurotrophin receptor. ENT-C225 has high effect on activating TrkB receptor (TrkBR), and has good physicochemical properties and neuroprotective properties.
  • HY-13999A1
    NSI-189 phosphate
    		Activator 99.75%
    NSI-189 is an orally active chemical entity with enhanced neurogenic activity. NSI-189 up-regulates neurogenic factors such as BDNF (brain derived-neurotrophic factor) and SCF. NSI-189 exhibits anti-depressant effect. NSI-189 enhances synaptic plasticity and reduces cognitive dysfunction. NSI-189 holds potential for psychiatric disorder research.
  • HY-110255A
    AZD 2066 hydrate
    		Activator ≥99.0%
    AZD-2066 hydrate is a selective, orally active and blood-brain barrier-permeating mGluR5 antagonist. AZD 2066 hydrate activates the BDNF/trkB signaling pathway. AZD 2066 hydrate can be used in the research of neuropathic pain, major depressive disorder and gastroesophageal reflux disease.
  • HY-107854S
    N-Acetyl-5-hydroxytryptamine-d3
    		Activator ≥98.0%
    N-Acetyl-5-hydroxytryptamine-d3 is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.
  • HY-172876
    FLY26
    		Activator
    FLY26 is a selective partial GluN2B antagonist with an IC50 value of 0.64 μM. FLY26 partially inhibits the GluN2B subunit of NMDA receptors, reduces calcium ion influx and reactive oxygen species (ROS) production and activates the BDNF/TrkB/CREB neuroprotective signaling pathway to alleviate neuronal excitotoxicity and mitochondrial dysfunction. FLY26 is promising for research of neurological deficits caused by cerebral ischemia-reperfusion injury.
  • HY-117517
    NG-012
    		Activator
    NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12).
  • HY-107854R
    N-Acetyl-5-hydroxytryptamine (Standard)
    		Activator
    N-Acetyl-5-hydroxytryptamine (Standard) is the analytical standard of N-Acetyl-5-hydroxytryptamine. This product is intended for research and analytical applications. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.
  • HY-124503
    Longanlactone
    		Activator
    Longanlactone is a natural pyrrole-lactone alkaloid that can be used as a neurotrophic agent. Longanlactone increases BDNF gene expression in neuro2a cells.
  • HY-110255B
    AZD-2066 hydrochloride
    		Activator
    AZD-2066 hydrochloride is a selective, orally active and blood-brain barrier-permeating mGluR5 antagonist. AZD 2066 hydrochloride activates the BDNF/trkB signaling pathway. AZD 2066 hydrochloride can be used in the research of neuropathic pain, major depressive disorder and gastroesophageal reflux disease.
  • HY-167836
    BNN-20
    		Activator
    BNN-20 is a synthetic microneurotrophin that mimics brain-derived neurotrophic factor (BDNF) and exhibits area-specific pleiotropic neuroprotective and pro-neurogenic effects. BNN-20 can be utilized in research related to Parkinson's disease.